Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia.

ABSTRACT:

Introduction

The locus coeruleus-noradrenaline (LC-NA) system is involved in a wide range of cognitive functions and may be altered in schizophrenia. A non-invasive method to indirectly measure LC activity is task-evoked pupillary response. Individuals with schizophrenia present reduced pupil dilation compared to healthy subjects, particularly when task demand increases. However, the extent to which alteration in LC activity contributes to schizophrenia symptomatology remains largely unexplored. We aimed to investigate the association between symptomatology, cognition, and noradrenergic response in individuals with schizophrenia.

Methods

We assessed task-evoked pupil dilation during a pro- and antisaccade task in 23 individuals with schizophrenia and 28 healthy subjects.

SUBMITTER: Pelegrino A 

PROVIDER: S-EPMC10661901 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature