The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance.

ABSTRACT:

Introduction

An insufficient functional beta cell mass is a core pathological hallmark of type 2 diabetes (T2D). Despite the availability of several effective pharmaceuticals for diabetes management, there is an urgent need for novel medications to protect pancreatic beta cells under diabetic conditions. Integrative organ cross-communication controls the energy balance and glucose homeostasis. The liver and pancreatic islets have dynamic cross-communications where the liver can trigger a compensatory beta cell mass expansion and enhanced hormonal secretion in insulin-resistant conditions. However, the indispensable element(s) that foster beta cell proliferation and insulin secretion have yet to be completely identified. Exosomes are important extracellular vehicles (EVs) released b

SUBMITTER: Mahmoudi-Aznaveh A 

PROVIDER: S-EPMC10661932 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature