Control of glnA (glutamine synthetase) expression by urea in non-pathogenic and uropathogenic Escherichia coli.

ABSTRACT: Previous transcriptomic studies have shown that glnA, which codes for glutamine synthetase (GS), is induced during growth of uropathogenic E. coli in urine. GS is at the intersection of carbon and nitrogen metabolism and is, not surprisingly, highly regulated. The glnALG operon specifies GS and two regulators of the nitrogen-regulated (Ntr) response, which scavenges nitrogenous compounds during nitrogen limitation. Transcription of glnA initiates from the cAMP receptor protein (Crp)-dependent glnAp1 and the GlnG-dependent glnAp2 promoters which respond to carbon and nitrogen limitation, respectively. High glnA expression is most often associated with nitrogen limitation, and its expression in urine could suggest nitrogen limitation, despite

SUBMITTER: Urs K 

PROVIDER: S-EPMC10662117 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature