Multiple TonB homologs are important for carbohydrate utilization by <i>Bacteroides thetaiotaomicron</i>.

ABSTRACT:

Importance

The human gut microbiota, including Bacteroides, is required for the degradation of otherwise undigestible polysaccharides. The gut microbiota uses polysaccharides as an energy source, and fermentation products such as short-chain fatty acids are beneficial to the human host. This use of polysaccharides is dependent on the proper pairing of a TonB protein with polysaccharide-specific TonB-dependent transporters; however, the formation of these protein complexes is poorly understood. In this study, we examine the role of 11 predicted TonB homologs in polysaccharide uptake. We show that two proteins, TonB4 and TonB6, may be functionally redundant. This may allow for the development of drugs targeting Bacteroides species containing only a TonB4 homolog with li

SUBMITTER: Pollet RM 

PROVIDER: S-EPMC10662123 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature