Safety and efficacy of direct oral anticoagulants in stroke prevention in patients with atrial fibrillation complicated with anemia and/or thrombocytopenia: a retrospective cohort study.

ABSTRACT:

Background

There are limited data about the clinical benefits and harm of direct oral anticoagulants (DOACs) in stroke prevention in patients with atrial fibrillation (AF) complicated with anemia or thrombocytopenia.

Methods

This is a multi-center retrospective cohort study involving 5469 AF patients from 15 hospitals in China. Patients were divided into three groups according to hemoglobin and platelet levels: Group 1 (hemoglobin male ≥ 130 g/L; female ≥ 120 g/L and platelet ≥ 100 × 10⁹/L), Group 2 (hemoglobin male < 130 g/L; female < 120 g/L or platelet < 100 × 10⁹/L), and Group 3 (hemoglobin male < 130 g/L; female < 120 g/L and platelet < 100 × 10⁹/L). Patients in each category are further divided into two groups according to their stroke

SUBMITTER: Xu W 

PROVIDER: S-EPMC10662166 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature