Causal association of calcific aortic valve stenosis and atrial fibrillation: a Mendelian randomization study.

ABSTRACT: Calcific aortic valve stenosis (CAVS) is associated with an increased risk of atrial fibrillation (AF) in observational studies, but whether these associations are causal has not been determined. This study aimed to explore the potential causal relationship between CAVS and AF via Mendelian randomization (MR). Genetic variants from the genome-wide association study (GWAS) summary data of the European population for CAVS were used to investigate the association with AF. The inverse variance weighted (IVW) approach was used to obtain the primary causal inference, and several sensitivity analysis approaches, such as the MR‒Egger and weighted median (WM), were performed to assess the robustness of the results. A total of nineteen valid and independent genetic SNPs associated with CAVS were obt

SUBMITTER: Chai C 

PROVIDER: S-EPMC10662195 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature