Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches.

ABSTRACT: Long-term liver injuries lead to hepatic fibrosis, often progressing into cirrhosis, liver failure, portal hypertension, and hepatocellular carcinoma. There is currently no effective therapy available for liver fibrosis. Thus, continuous investigations for anti-fibrotic therapy are ongoing. The main theme of anti-fibrotic investigation during recent years is the rationale-based selection of treatment molecules according to the current understanding of the pathology of the disease. The research efforts are mainly toward repurposing current FDA-approved drugs targeting etiological molecular factors involved in developing liver fibrosis. In parallel, investigations also focus on experimental small molecules with evidence to hinder or reverse the fibrosis. Natural compounds, immunological, and

SUBMITTER: Mohammed OS 

PROVIDER: S-EPMC10662312 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature