Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.

ABSTRACT:

Background

Focal cortical dysplasia (FCD) IIb and tuberous sclerosis complex (TSC) are common causes of drug-resistant epilepsy in children. However, the etiologies related to the development of FCD IIb and TSC are not fully understood. α-synuclein (α-syn) is a member of synucleins family that plays crucial roles in modulating synaptic transmission in central nervous system. Here, we explored the expression profiles and potential pathogenic functions of α-syn in cortical lesions of epileptic patients with FCD IIb and TSC.

Methods

Surgical specimens from epileptic patients with FCD IIb and TSC, as well as FCD rats generated by in utero X-ray-radiation were adopted in this study and studied with immunohistochemistry, immunofluorescence, western blotting, and co-immunopr

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10662349 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature