Whole genome sequencing-based identification of human tuberculosis caused by animal-lineage Mycobacterium orygis.

ABSTRACT: A recently described member of the Mycobacterium tuberculosis complex (MTBC) is Mycobacterium orygis, which can cause disease primarily in animals but also in humans. Although M. orygis has been reported from different geographic regions around the world, due to a lack of proper identification techniques, the contribution of this emerging pathogen to the global burden of zoonotic tuberculosis is not fully understood. In the present work, we report single nucleotide polymorphism (SNP) analysis using whole genome sequencing (WGS) that can accurately identify M. orygis and differentiate it from other members of the MTBC species. WGS-based SNP analysis was performed for 61 isolates from different provinces in Canada that were identified as M. orygis. A total

SUBMITTER: Islam MR 

PROVIDER: S-EPMC10662373 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature