How AlphaFold2 shaped the structural coverage of the human transmembrane proteome.

ABSTRACT: AlphaFold2 (AF2) provides a 3D structure for every known or predicted protein, opening up new prospects for virtually every field in structural biology. However, working with transmembrane protein molecules pose a notorious challenge for scientists, resulting in a limited number of experimentally determined structures. Consequently, algorithms trained on this finite training set also face difficulties. To address this issue, we recently launched the TmAlphaFold database, where predicted AlphaFold2 structures are embedded into the membrane plane and a quality assessment (plausibility of the membrane-embedded structure) is provided for each prediction using geometrical evaluation. In this paper, we analyze how AF2 has improved the structural coverage of membrane proteins compared to earlier

SUBMITTER: Jambrich MA 

PROVIDER: S-EPMC10662385 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature