Benchmarking of a microgel-reinforced hydrogel-based aqueous lubricant against commercial saliva substitutes.

ABSTRACT: Xerostomia, the subjective sensation of 'dry mouth' affecting at least 1 in 10 adults, predominantly elders, increases life-threatening infections, adversely impacting nutritional status and quality of life. A patented, microgel-reinforced hydrogel-based aqueous lubricant, prepared using either dairy or plant-based proteins, has been demonstrated to offer substantially enhanced lubricity comparable to real human saliva in in vitro experiments. Herein, we present the benchmarking of in vitro lubrication performance of this aqueous lubricant, both in its dairy and vegan formulation against a range of widely available and employed commercial saliva substitutes, latter classified based on their shear rheology into "liquids", "viscous liquids" and "gels", and also had varying extensional proper

SUBMITTER: Pabois O 

PROVIDER: S-EPMC10662424 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature