Delaying circadian sleep phase under ultradian light cycle causes time-of-day-dependent alteration of cognition and mood.

ABSTRACT: Light exerts powerful and pervasive effects on physiology and behaviour. These effects can be indirect, through clock synchronization and phase adjustment of circadian rhythms, or direct, independent of the circadian process. Exposure to light at inappropriate times, as commonly experienced in today's society, leads to increased prevalence of circadian, sleep and mood disorders as well as cognitive impairments. In mice, exposure to an ultradian 3.5 h light/3.5 h dark cycle (T7) for several days has been shown to impair behaviour through direct, non-circadian, photic effects, a claim we challenge here. We first confirmed that T7 cycle induces a lengthening of the circadian period resulting in a day by day phase-delay of both activity and sleep rhythms. Spatial novelty preference test perfor

SUBMITTER: Fuchs F 

PROVIDER: S-EPMC10662432 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature