Differential Impact of Brain Network Efficiency on Poststroke Motor and Attentional Deficits.

ABSTRACT:

Background

Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding.

Methods

Fifty subacute stroke patients (7±3days poststroke) underwent diffusion-weighted magnetic resonance imaging and a battery of clinical tests of motor and cognitive functions. We defined indices of impairment in strength, dexterity, and attention. We also computed imaging-based probabilistic tractography and whole-brain connectomes. To efficiently integrate inputs from different sources, brain networks rely on a rich-club of a few hub nodes. Lesions harm efficiency, pa

SUBMITTER: Evangelista GG 

PROVIDER: S-EPMC10662579 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature