PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection.

ABSTRACT:

Background

In the diagnosis of bloodstream infection (BSI), various inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL), white blood cell count (WBC), neutrophil percentage (NE%), platelet count (PLT), and erythrocyte sedimentation rate (ESR) have been extensively utilized. However, their specific roles in distinguishing BSI from local bacterial infection (LBI) and in classifying BSI pathogens remain uncertain.

Methods

A historical cohort study was conducted, involving the enrollment of 505 patients with BSI and 102 patients with LBI. To validate the reliability of the clinical data obtained from this cohort, mouse models of BSI were utilized.

Results

Our findings revealed that patients with BSI had significantly higher levels

SUBMITTER: Yang X 

PROVIDER: S-EPMC10662675 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature