Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway.

ABSTRACT:

Objective

Inflammation and oxidative stress contribute to the pathogenesis of acute lung injury (ALI), and subsequently result in rapid deterioration in health. Considering the indispensable role of bisdemethoxycurcumin (BDMC) in inflammation and oxidative stress, the present study aims to examine the effect of BDMC on sepsis-related ALI.

Methods

C57BL/6 mice were administered with BDMC (100 mg/kg) or an equal volume of vehicle, and then injected with lipopolysaccharides (LPS) to induce ALI. We assessed the parameters of lung injury, inflammatory response and oxidative stress in lung tissues. Consistently, the macrophages with or without BDMC treatment were exposed to LPS to verify the effect of BDMC in vitro.

Results

BDMC suppressed LPS-induced lung injury, inflammat

SUBMITTER: Li H 

PROVIDER: S-EPMC10662695 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature