Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis.

ABSTRACT:

Background

The current World Health Organization (WHO) pediatric tuberculosis dosing guidelines lead to suboptimal drug exposures. Identifying factors altering the exposure of these drugs in children is essential for dose optimization. Pediatric pharmacokinetic studies are usually small, leading to high variability and uncertainty in pharmacokinetic results between studies. We pooled data from large pharmacokinetic studies to identify key covariates influencing drug exposure to optimize tuberculosis dosing in children.

Methods and findings

We used nonlinear mixed-effects modeling to characterize the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide, and investigated the association of human immunodeficiency virus (HIV), antiretroviral therapy (ART), drug formulatio

SUBMITTER: Galileya LT 

PROVIDER: S-EPMC10662720 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature