Influence of previous Zika virus infection on acute dengue episode.

ABSTRACT:

Background

The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection.

Methodology/principal findings

We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue.

Conclusions/significance

Our findings suggest that previous Zika infection may represent a risk factor for subsequent sever

SUBMITTER: Estofolete CF 

PROVIDER: S-EPMC10662752 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature