A systematic review of the clinical profile of patients with bubonic plague and the outcome measures used in research settings.

ABSTRACT:

Background

Plague is a zoonotic disease that, despite affecting humans for more than 5000 years, has historically been the subject of limited drug development activity. Drugs that are currently recommended in treatment guidelines have been approved based on animal studies alone-no pivotal clinical trials in humans have yet been completed. As a result of the sparse clinical research attention received, there are a number of methodological challenges that need to be addressed in order to facilitate the collection of clinical trial data that can meaningfully inform clinicians and policy-makers. One such challenge is the identification of clinically-relevant endpoints, which are informed by understanding the clinical characterisation of the disease-how it presents and evolves over time

SUBMITTER: Bourner J 

PROVIDER: S-EPMC10662759 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature