Causal relationship between insomnia and tuberculosis: A bi-directional Mendelian randomization analysis.

ABSTRACT: Previous observational studies appear to have established a bi-directional association between sleep disorders and tuberculosis. However, their conclusions are prone to be biased by confounding effects and reverse causation due to the nature of observational studies. Mendelian randomization (MR) approach provides unconfounded estimates of causal effects and overcomes the limitations of observational studies. We performed a bi-directional MR analysis to clarify whether there existed a causal effect of insomnia on tuberculosis, or tuberculosis on insomnia. In forward-direction MR, we chose genome-wide significant (P < .5 × 10-8) and independent (r2 < 0.001) single-nucleotide polymorphisms (SNPs) as instrumental variants (IVs), then extracted effect estimates of these IVs in tuberculosis geno

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10662851 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature