Construction and evaluation of a novel prognostic risk model of aging-related genes in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BLCA) is the most common malignancy of the urinary system. Muscle-invasive bladder cancer (MIBC), which constitutes approximately 25% of all BLCA cases, is characterized by frequent recurrence and early onset of metastasis. Bladder cancer most commonly occurs in elderly patients and is significantly associated with aging. However, the prognostic value of age-related genes in BLCA, especially in MIBC, remains unclear.

Materials and methods

Training and testing sets were obtained from The Cancer Genome Atlas BLCA project. Differentially expressed genes between BLCA and normal samples intersected with human aging-related genes. Univariate Cox regression and least absolute shrinkage and selection operator regression analyses were used to identify progn

SUBMITTER: Wang D 

PROVIDER: S-EPMC10662852 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature