A systematic review of epidemiology and outcomes of Crohn's disease-related enterocutaneous fistulas.

ABSTRACT:

Background

Enterocutaneous fistulas (ECF) are rare sequelae of Crohn's disease (CD) that occur either postoperatively or spontaneously. ECFs are associated with high morbidity and mortality. This systematic literature review assesses the disease burden of CD-related ECF and identifies knowledge gaps around incidence/prevalence, treatment patterns, clinical outcomes, healthcare resource utilization (HCRU), and patient-reported outcomes (PROs).

Methods

English language articles published in PubMed and Embase in the past 10 years that provided data and insight into the disease burden of CD-related ECF (PROSPERO Registration number: CRD42020177732) were identified. Prespecified search and eligibility criteria guided the identification of studies by two reviewers who also assesse

SUBMITTER: Iglay K 

PROVIDER: S-EPMC10662878 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature