Age at menopause and all-cause and cause-specific dementia: a prospective analysis of the UK Biobank cohort.

ABSTRACT:

Study question

Are there associations between natural or surgical menopause and incident dementia by age at menopause?

Summary answer

Compared to age at menopause of 46-50 years, earlier natural menopause (≤40 and 41-45 years) was related to higher risk of all-cause dementia, while a U-shape relationship was observed between age at surgical menopause and risk of dementia.

What is known already

Menopause marks the end of female reproductive period. Age at menopause reflects the length of exposure to endogenous estrogen. Evidence on the association between age at natural, surgical menopause, and risk of dementia has been inconsistent.

Study design, size, duration

A population-based cohort study involving 160 080 women who participated in the UK Biobank study.

SUBMITTER: Hao W 

PROVIDER: S-EPMC10663050 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature