Apnea of prematurity induces short and long-term development-related transcriptional changes in the murine cerebellum.

ABSTRACT: Apnea of prematurity (AOP) affects more than 50% of preterm infants and leads to perinatal intermittent hypoxia (IH) which is a major cause of morbimortality worldwide. At birth, the human cerebellar cortex is still immature, making it vulnerable to perinatal events. Additionally, studies have shown a correlation between cerebellar functions and the deficits observed in children who have experienced AOP. Yet, the cerebellar alterations underpinning this link remain poorly understood. To gain insight into the involvement of the cerebellum in perinatal hypoxia-related consequences, we developed a mouse model of AOP. Our previous research has revealed that IH induces oxidative stress in the developing cerebellum, as evidenced by the over-expression of genes involved in reactive oxygen species

SUBMITTER: Rodriguez-Duboc A 

PROVIDER: S-EPMC10663136 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature