The glucose transporter 2 regulates CD8⁺ T cell function via environment sensing.

ABSTRACT: T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the glycolytic pathway are major checkpoints for this event. Here we show that the low-affinity, concentration-dependent glucose transporter 2 (Glut2) regulates the development of CD8⁺ T cell effector responses in mice by promoting glucose uptake, glycolysis and glucose storage. Expression of Glut2 is modulated by environmental factors including glucose and oxygen availability and extracellular acidification. Glut2 is highly expressed by circulating, recently primed T cells, allowing efficient glucose uptake and storage. In glucose-deprived inflammatory environments,

SUBMITTER: Fu H 

PROVIDER: S-EPMC10663157 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature