Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment.

ABSTRACT: The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed the landscape in the development of novel adoptive cell therapies for treating cancer over the last decade. NK cells have become a key player for cancer immunotherapy due to their innate ability to kill malignant cells while not harming healthy cells, allowing their potential use as an "off-the-shelf" product. Furthermore, recent advancements in NK cell genetic engineering methods have enabled the efficient generation of chimeric antigen receptor (CAR)-expressing NK cells that can exert both CAR-dependent and antigen-independent killing. Clinically, CAR-NK cells have shown promising efficacy and safety for treating CD19-expressing hematologic malignancies. While the number of pre-clinical s

SUBMITTER: Portillo AL 

PROVIDER: S-EPMC10663242 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature