Survival and prognostic factors of progressive multifocal leukoencephalopathy in people living with HIV in modern ART era.

ABSTRACT:

Background

The incidence of progressive multifocal leukoencephalopathy (PML) in people living with HIV (PLWH) is 2%-4%. Currently, there is no effective therapeutic strategy for the treatment of PML in PLWH, resulting in a mortality of up to 50%. This study aimed to identify risk factors of death and prognostic markers in people living with HIV with PML.

Methods

A retrospective cohort study of AIDS-related PML individuals was conducted from January 1, 2015, to October 1, 2022, in Shanghai, China. PLWH who were diagnosed with PML for the first time were included. Kaplan-Meier curve and Cox regression were used to analyze the survival and its predictors. Levels of inflammatory markers and immune checkpoint inhibitors in blood and cerebrospinal fluid (CSF) were measured in the

SUBMITTER: Jiang R 

PROVIDER: S-EPMC10663249 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature