Identification of the key immune-related genes and immune cell infiltration changes in renal interstitial fibrosis.

ABSTRACT:

Background

Chronic kidney disease (CKD) is the third-leading cause of premature mortality worldwide. It is characterized by rapid deterioration due to renal interstitial fibrosis (RIF) via excessive inflammatory infiltration. The aim of this study was to discover key immune-related genes (IRGs) to provide valuable insights and therapeutic targets for RIF in CKD.

Materials and methods

We screened differentially expressed genes (DEGs) between RIF samples from CKD patients and healthy controls from a public database. Least absolute shrinkage and selection operator regression analysis and receiver operating characteristic curve analysis were applied to identify significant key biomarkers. The single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm was used to analyze the i

SUBMITTER: Dong Z 

PROVIDER: S-EPMC10663291 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature