Magnetic resonance elastography-based prediction model for hepatic decompensation in NAFLD: A multicenter cohort study.

ABSTRACT:

Background and aims

Magnetic resonance elastography (MRE) is an accurate, continuous biomarker of liver fibrosis; however, the optimal combination with clinical factors to predict the risk of incident hepatic decompensation is unknown. Therefore, we aimed to develop and validate an MRE-based prediction model for hepatic decompensation for patients with NAFLD.

Approach and results

This international multicenter cohort study included participants with NAFLD undergoing MRE from 6 hospitals. A total of 1254 participants were randomly assigned as training (n = 627) and validation (n = 627) cohorts. The primary end point was hepatic decompensation, defined as the first occurrence of variceal hemorrhage, ascites, or HE. Covariates associated with hepatic decompensation on Cox-regre

SUBMITTER: Kim BK 

PROVIDER: S-EPMC10663382 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature