Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease.

ABSTRACT:

Introduction

A hallmark of Alzheimer's disease (AD) is the aggregation of proteins (amyloid beta [A] and hyperphosphorylated tau [T]) in the brain, making cerebrospinal fluid (CSF) proteins of particular interest.

Methods

We conducted a CSF proteome-wide analysis among participants of varying AT pathology (n = 137 participants; 915 proteins) with nine CSF biomarkers of neurodegeneration and neuroinflammation.

Results

We identified 61 proteins significantly associated with the AT category (P < 5.46 × 10^-5 ) and 636 significant protein-biomarker associations (P < 6.07 × 10^-6 ). Proteins from glucose and carbon metabolism pathways were enriched among amyloid- and tau-associated proteins, including malate dehydrogenase and aldolase A, whose associati

SUBMITTER: Panyard DJ 

PROVIDER: S-EPMC10663389 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature