EMT-related gene risk model establishment for prognosis and drug treatment efficiency prediction in hepatocellular carcinoma.

ABSTRACT: This study was designed to evaluate the prognosis and pharmacological therapy sensitivity of epithelial mesenchymal transition-related genes (EMTRGs) that obtained from the EMTome database in hepatocellular carcinoma (HCC) using bioinformatical method. The expression status of EMTRGs were also investigated using the clinical information of HCC patients supported by TCGA database and the ICGC database to establish the TCGA cohort as the training set and the ICGC cohort as the validation set. Analyze the EMTRGs between HCC tissue and liver tissue in the TCGA cohort in the order of univariate COX regression, LASSO regression, and multivariate COX regression, and construct a risk model for EMTRGs. In addition, enrichment pathways, gene mutation status, immune infiltration, and response to drug

SUBMITTER: Gao X 

PROVIDER: S-EPMC10663558 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature