Ca_V3.1 channels facilitate calcium wave generation and myogenic tone development in mouse mesenteric arteries.

ABSTRACT: The arterial myogenic response to intraluminal pressure elicits constriction to maintain tissue perfusion. Smooth muscle [Ca²⁺] is a key determinant of constriction, tied to L-type (Ca_V1.2) Ca²⁺ channels. While important, other Ca²⁺ channels, particularly T-type could contribute to pressure regulation within defined voltage ranges. This study examined the role of one T-type Ca²⁺ channel (Ca_V3.1) using C57BL/6 wild type and Ca_V3.1^-/- mice. Patch-clamp electrophysiology, pressure myography, blood pressure and Ca²⁺ imaging defined the Ca_V3.1^-/- phenotype relative to C57BL/6. Ca_V3.1^-/- mice had absent Ca_V3.1 expression and whole-cell current,

SUBMITTER: El-Lakany MA 

PROVIDER: S-EPMC10663617 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature