Prediction of folding patterns for intrinsic disordered protein.

ABSTRACT: The conformation flexibility of natural protein causes both complexity and difficulty to understand the relationship between structure and function. The prediction of intrinsically disordered protein primarily is focusing on to disclose the regions with structural flexibility involving relevant biological functions and various diseases. The order of amino acids in protein sequence determines possible conformations, folding flexibility and biological function. Although many methods provided the information of intrinsically disordered protein (IDP), but the results are mainly limited to determine the locations of regions without knowledge of possible folding conformations. Here, the developed protein folding fingerprint adopted the protein folding variation matrix (PFVM) to reveal all possib

SUBMITTER: Yang J 

PROVIDER: S-EPMC10663623 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature