Epigenome-wide studies of antipsychotics: a systematic review and pathway meta-analysis.

ABSTRACT: Background & methods: Researchers have aimed to understand the mechanisms of antipsychotics through epigenetics to inform interindividual response rates. However, findings have widely varied across studies, making advancement in the field difficult. Materials & methods: A systematic review was performed to include all epigenome-wide studies of antipsychotic treatment in humans. Methylation sites were used for a pathway and enrichment map analysis was conducted. Results & conclusion: Seven studies were included and 82 methylation sites were used for the exploratory pathway meta-analysis that identified six pathway clusters. The findings here demonstrate that studies of the epigenome and antipsychotic treatment are highly heterogeneous in nature and could inform future w

SUBMITTER: Rowbal T 

PROVIDER: S-EPMC10663877 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature