Fecal short chain fatty acids modify therapeutic effects of sleeve gastrectomy.

ABSTRACT:

Aims

We aimed to investigate changes of fecal short chain fatty acids (SCFAs) and their association with metabolic benefits after sleeve gastrectomy (SG). Specifically, whether pre-surgery SCFAs modify surgical therapeutic effects was determined.

Methods

62 participants with measurements of fecal SCFAs and metabolic indices before and 1, 3, 6 months after SG were included. Changes of fecal SCFAs and their association with post-surgery metabolic benefits were calculated. Then, participants were stratified by medians of pre-surgery fecal SCFAs and modification effects of pre-surgery fecal SCFAs on surgical therapeutic effects were investigated, through calculating interaction of group by surgery.

Results

Fecal SCFAs were markedly changed by SG. Changes of propionate and

SUBMITTER: Shen C 

PROVIDER: S-EPMC10663943 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature