Aberrant structural rich club organization in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures.

ABSTRACT:

Objective

The purpose of this study was to assess the differences of topological characteristic and rich club organization between temporal lobe epilepsy (TLE) patients with focal seizure (FS) only and those with focal to bilateral tonic-clonic seizures (FBTCS).

Methods

We recruited 130 unilateral TLE patients, of which 57 patients with FS only and 73 patients with both FS and FBTCS, and 68 age- and gender-matched healthy controls (HC). Whole-brain networks were constructed based on diffusion weighted imaging data. Graph theory was applied to quantify the topological network metrics and rich club organization. Network-based statistic (NBS) analysis was administered to investigate the difference in edge-wise connectivity strength. The non-parametric permutation test was appli

SUBMITTER: Lin Q 

PROVIDER: S-EPMC10663961 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature