DOSE-L1000: unveiling the intricate landscape of compound-induced transcriptional changes.

ABSTRACT:

Motivation

The LINCS L1000 project has collected gene expression profiles for thousands of compounds across a wide array of concentrations, cell lines, and time points. However, conventional analysis methods often fall short in capturing the rich information encapsulated within the L1000 transcriptional dose-response data.

Results

We present DOSE-L1000, a database that unravels the potency and efficacy of compound-gene pairs and the intricate landscape of compound-induced transcriptional changes. Our study uses the fitting of over 140 million generalized additive models and robust linear models, spanning the complete spectrum of compounds and landmark genes within the LINCS L1000 database. This systematic approach provides quantitative insights into differential gene express

SUBMITTER: Wang J 

PROVIDER: S-EPMC10663987 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature