Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice.

ABSTRACT: Alzheimer's disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient's daily functioning with progressive cognitive decline, which can be partly attributed to impaired hippocampal neurogenesis. Neurogenesis in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging, especially in Alzheimer's disease. Recent evidence indicated that RNA-binding protein 8A (Rbm8a) promotes the proliferation of neural progenitor cells, with lower expression levels observed in Alzheimer's disease patients compared with healthy people. This study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer's disease.

SUBMITTER: Zhu C 

PROVIDER: S-EPMC10664127 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature