Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.

ABSTRACT: Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body. They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases. Some of these include central nervous system (CNS) diseases and dysfunctions such as forms of epilepsy, multiple sclerosis, Parkinson's disease, pain and neuropsychiatric disorders. In addition, the endogenously produced cannabinoid lipids, endocannabinoids, are critical for normal CNS function, and if controlled or modified, may represent an additional therapeutic avenue for CNS diseases. This review discusses in vitro cellular, ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutic

SUBMITTER: Duncan RS 

PROVIDER: S-EPMC10664133 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature