IRF8 as a Novel Marker to Differentiate Between CD30-Positive Large Cell Lymphomas.

ABSTRACT:

Objectives

Interferon regulatory factor 8 (IRF8) is a new biomarker shown to be positive in monocytic leukemias as well as in B cells. As a transcription factor, it plays a critical role in pre-B-cell differentiation and induction of tolerance pathways, among other functions. Given the frequent diagnostic dilemma in CD30-positive large cell lymphomas that could resemble both Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL), we sought to determine whether IRF8 can be useful in distinguishing between these neoplasms that require different treatment strategies.

Methods

In this retrospective study, 74 cases of classic Hodgkin lymphoma (CHL) and 7 cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) on a tissue microarray (TMA), as well as 15 individual case

SUBMITTER: McQuaid DC 

PROVIDER: S-EPMC10664184 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature