Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Nicotine dependence is a key factor influencing the diversity of gut microbiota, and targeting gut microbiota may become a new approach for the prevention and treatment of nicotine dependence. However, the causal relationship between the two is still unclear. This study aims to investigate the causal relationship between nicotine dependence and gut microbiota.

Methods

A two-sample bidirectional Mendelian randomization (MR) study was conducted using the largest existing gut microbiota and nicotine dependence genome-wide association studies (GWAS). Causal relationships between genetically predicted nicotine dependence and gut microbiota abundance were examined using inverse variance weighted, MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO appro

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10664251 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature