Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Mitochondrial dysfunction leading to disturbances in energy metabolism has emerged as one of the risk factors in the pathogenesis of depression. Numerous studies have identified alterations in the content of mitochondrial DNA (mtDNA) in peripheral blood and cerebrospinal fluid of individuals with depression. Researchers have sought to establish a clear association between mtDNA and depression. Consequently, we conducted a comprehensive meta-analysis to assess the existing evidence regarding the impact of mtDNA on depression.

Methods

This study conducted a thorough search of the following databases up to March 13, 2023: PubMed, Embase, the Cochrane Library, the Web of Science, Wanfang Database, SINOMED, the China Science and Technology Journal Database, and China N

SUBMITTER: Li W 

PROVIDER: S-EPMC10664364 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature