Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.

ABSTRACT:

Background

Autonomic nervous system (ANS) dysfunction and vascular stiffness increase cardiovascular risk in people with chronic kidney disease (CKD). Chronic elevations in sympathetic activity can lead to increased arterial stiffness; however, the relationship between these variables is unknown in CKD.

Objective

To explore the association between measures of autonomic function and arterial stiffness in patients with moderate-to-severe CKD.

Methods

This study was a prespecified secondary analysis of a randomized controlled trial. This included the following measures: 24-hour ambulatory blood pressure (BP), carotid-femoral and carotid-radial pulse wave velocity (PWV), and postexercise heart rate recovery (HRR). We used mixed effect linear regression models with Bayesia

SUBMITTER: Davies R 

PROVIDER: S-EPMC10664430 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature