A dual-responsive ratiometric indicator designed for in vivo monitoring of oxidative stress and antioxidant capacity.

ABSTRACT: The imbalance between oxidative stress and antioxidant capacity is strongly associated with the development of numerous degenerative diseases, including cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Therefore, monitoring oxidative stress and antioxidant capacity in vivo is crucial for maintaining cellular homeostasis and the stability of the organism's internal environment. Here, we present the findings of our study on DQ1, a dual-responsive indicator designed specifically for imaging H₂O₂ and NAD(P)H, which are critical indicators of oxidative stress and antioxidant capacity. DQ1 facilitated the colorimetric and fluorescence detection of H₂O₂ and NAD(P)H in two well-separated channels, exhibiting a detection l

SUBMITTER: Yang M 

PROVIDER: S-EPMC10664494 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature