Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice.

ABSTRACT: Traumatic spinal cord injury can cause immediate physical damage to the spinal cord and result in severe neurological deficits. The primary, mechanical tissue damage triggers a variety of secondary damage mechanisms at the injury site which significantly contribute to a larger lesion size and increased functional damage. Inflammatory mechanisms which directly involve both microglia (MG) and monocyte-derived macrophages (MDM) play important roles in the post-injury processes, including inflammation and debris clearing. In the current study, we investigated changes in the structure and function of MG/MDM in the injured spinal cord of adult female mice, 7 days after a thoracic contusion SCI. With the use of chip mapping scanning electron microscopy, which allows to image large samples at the

SUBMITTER: St-Pierre MK 

PROVIDER: S-EPMC10664529 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature