Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis.

ABSTRACT:

Introduction

Shock-induced endotheliopathy (SHINE), defined as a profound sympathoadrenal hyperactivation in shock states leading to endothelial activation, glycocalyx damage, and eventual compromise of end-organ perfusion, was first described in 2017. The aggressive resuscitation therapies utilised in treating shock states could potentially lead to further worsening endothelial activation and end-organ dysfunction.

Objective

This study aimed to systematically review the literature on resuscitation-associated and resuscitation-induced endotheliopathy.

Methods

A predetermined structured search of literature published over an 11-year and 6-month period (1 January 2011 to 31 July 2023) was performed in two indexed databases (PubMed/MEDLINE and Embase) per PRISMA guidelin

SUBMITTER: Obonyo NG 

PROVIDER: S-EPMC10664580 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature