Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Several observational studies have reported an association between hand grip strength (HGS) and pulmonary function (PF). However, causality is unclear. To investigate whether HGS and PF are causally associated, we performed Mendelian randomization (MR) analyses.

Methods

We identified 110 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength (RHGS) and 103 independent SNPs for left-hand grip strength (LHGS) at the genome-wide significant threshold (P < 5 × 10^-8) from MRC-IEU Consortium and evaluated these related to PF. MR estimates were calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analyses were further performed.

Results

Genetical liability to HGS was positively causally associated

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10664596 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature