Intrauterine growth restriction alters kidney metabolism at the end of nephrogenesis.

ABSTRACT:

Background

This study investigated the effect of uteroplacental insufficiency (UPI) on renal development by detecting metabolic alterations in the kidneys of rats with intrauterine growth restriction (IUGR).

Methods

On gestational day 17, pregnant Sprague Dawley rats were selected and allocated randomly to either the IUGR group or the control group. The IUGR group received a protocol involving the closure of bilateral uterine vessels, while the control group underwent a sham surgery. The rat pups were delivered on gestational day 22 by natural means. Pups were randomly recruited from both the control and IUGR groups on the seventh day after birth. The kidneys were surgically removed to conduct Western blot and metabolomic analyses.

Results

IUGR was produced by UPI, as

SUBMITTER: Ho SY 

PROVIDER: S-EPMC10664663 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature