Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.

ABSTRACT:

Background

Aplasia cutis congenita (ACC) is a rare genetic disorder characterized by the localized or widespread absence of skin in humans and animals. Individuals with ACC may experience developmental abnormalities in the skeletal and muscular systems, as well as potential complications. Localized and isolated cases of ACC can be treated through surgical and medical interventions, while extensive cases of ACC may result in neonatal mortality. The presence of ACC in pigs has implications for animal welfare. It contributes to an elevated mortality rate among piglets at birth, leading to substantial economic losses in the pig farming industry. In order to elucidate candidate genetic loci associated with ACC, we performed a Genome-Wide Association Study analysis on 216 Duroc pigs. The

SUBMITTER: Zhou F 

PROVIDER: S-EPMC10664689 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature