The first report of polymorphisms of the prion protein gene (PRNP) in Pekin ducks (Anas platyrhynchos domestica).

ABSTRACT:

Background

Prion diseases have been extensively reported in various mammalian species and are caused by a pathogenic prion protein (PrP^Sc), which is a misfolded version of cellular prion protein (PrP^C). Notably, no cases of prion disease have been reported in birds. Single nucleotide polymorphisms (SNPs) of the prion protein gene (PRNP) that encodes PrP have been associated with susceptibility to prion diseases in several species. However, no studies on PRNP polymorphisms in domestic ducks have been reported thus far.

Method

To investigate PRNP polymorphisms in domestic ducks, we isolated genomic DNA from 214 Pekin duck samples and sequenced the coding region of the Pekin duck PRNP gene. We analyzed genotype, allele, and hapl

SUBMITTER: Jeong MJ 

PROVIDER: S-EPMC10664711 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature