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Alopecia Areata: A Complex Cytokine Driven Disease.

ABSTRACT: Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.

SUBMITTER: Song T

PROVIDER: S-EPMC10664751 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Alopecia Areata: A Complex Cytokine Driven Disease.

Song Teresa T Guttman-Yassky Emma E

The journal of investigative dermatology. Symposium proceedings 20201101 1

Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines. ...[more]

PMID: 33099386

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